Circadian and seasonal variations in patients with acute STEMI: A retrospective, single PPCI center study

Napohn Chongprasertpon, John Joseph Coughlan, Ciara Cahill, Thomas John Kiernan

Research output: Contribution to journalArticlepeer-review

Abstract

This was a retrospective observational analysis of all (n = 876) ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) at University Hospital Limerick (UHL) from 2012 to 2016 to determine whether chronological patterns existed in incidence and mortality at our center. Data were obtained from the electronic Cardiology STEMI database in UHL. Statistical analysis was performed using the Independent Samples t Test, ANOVA and Pearson’s Chi-Squared test. The rate of STEMI from 0800 and 2259 hours (46.9/hr) was greater than 2300 to 0759 hours (19.1/hr) (p < 0.001). No association was found between 30-day mortality and weekend/weekdays presentation (p = 0.81) or off/in hour presentation (p = 0.86). No seasonal variation was found in STEMI incidence at our center using international (p = 0.29) or Celtic (p = 0.82) seasonal calendars. 30-Day mortality is equivalent whether STEMI patients treated with PPCI present during “normal working hours” or during the “out of hours”/weekend period at our center. The majority of STEMIs occur during the hours 0800 to 2259, but no further chronological relationship was observed in incidence.

Original languageEnglish
Pages (from-to)1663-1669
Number of pages7
JournalChronobiology International
Volume35
Issue number12
DOIs
Publication statusPublished - 2 Dec 2018

Keywords

  • circadian variation
  • out of hours
  • primary percutaneous coronary intervention
  • seasonal variation
  • ST-segment elevation myocardial infarction
  • weekend

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