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Clinical-grade validation of whole genome sequencing reveals robust detection of low-frequency variants and copy number alterations in CLL

  • Jenny Klintman
  • , Katerina Barmpouti
  • , Samantha J.L. Knight
  • , Pauline Robbe
  • , Hélène Dreau
  • , Ruth Clifford
  • , Kate Ridout
  • , Adam Burns
  • , Adele Timbs
  • , David Bruce
  • , Pavlos Antoniou
  • , Alona Sosinsky
  • , Jennifer Becq
  • , David Bentley
  • , Peter Hillmen
  • , Jenny C. Taylor
  • , Mark Caulfield
  • , Anna H. Schuh
  • University of Oxford
  • Oxford University Hospitals NHS Foundation Trust
  • NIHR Oxford Biomedical Research Centre
  • University Hospitals Limerick
  • Genomics England
  • Illumina
  • Leeds Teaching Hospitals NHS Trust

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Biochemistry, Genetics and Molecular Biology