TY - JOUR
T1 - Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice
AU - Wang, Yijun
AU - Liu, Tiantian
AU - Xie, Yanmei
AU - Li, Na
AU - Liu, Yan
AU - Wen, Jiaqiang
AU - Zhang, Man
AU - Feng, Wanjie
AU - Huang, Jinbao
AU - Guo, Yuanxin
AU - Kabbas Junior, Tufy
AU - Wang, Dongxu
AU - Granato, Daniel
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/12
Y1 - 2022/12
N2 - This study examined the chemical compounds and bioactivity of the aqueous extract of Clitoria ternatea blue petals and investigated its beneficial effects in vivo on a mouse model of obesity and metabolic syndrome. The extract mainly contained flavonoids, and nine compounds were tentatively identified. Male C57BL/6J mice were either fed a standard diet (SD) or a high-fat, high-fructose diet (HFFD) for 16 weeks, and HFFD-fed animals were treated with 0.25%, 0.5%, and 2% (w/w) of the aqueous extract in drinking water. The aqueous extract ameliorated oxidative stress and inflammation mediators. Furthermore, the aqueous extract reduced plasma leptin, free fatty acid, low-density lipoprotein cholesterol levels and hepatic malondialdehyde content. The aqueous extract significantly reduced total cholesterol and ameliorated insulin resistance. The results demonstrated that the aqueous extract of C. ternatea blue petals contains bioactive anthocyanins that exert substantial hypolipidemic and anti-inflammatory effects by promoting reverse cholesterol transport in HFFD-fed mice.
AB - This study examined the chemical compounds and bioactivity of the aqueous extract of Clitoria ternatea blue petals and investigated its beneficial effects in vivo on a mouse model of obesity and metabolic syndrome. The extract mainly contained flavonoids, and nine compounds were tentatively identified. Male C57BL/6J mice were either fed a standard diet (SD) or a high-fat, high-fructose diet (HFFD) for 16 weeks, and HFFD-fed animals were treated with 0.25%, 0.5%, and 2% (w/w) of the aqueous extract in drinking water. The aqueous extract ameliorated oxidative stress and inflammation mediators. Furthermore, the aqueous extract reduced plasma leptin, free fatty acid, low-density lipoprotein cholesterol levels and hepatic malondialdehyde content. The aqueous extract significantly reduced total cholesterol and ameliorated insulin resistance. The results demonstrated that the aqueous extract of C. ternatea blue petals contains bioactive anthocyanins that exert substantial hypolipidemic and anti-inflammatory effects by promoting reverse cholesterol transport in HFFD-fed mice.
KW - Anti-obesity
KW - Flavonoids
KW - Functional foods
KW - In vivo study
KW - Low-grade inflammation
KW - Reactive oxygen species
KW - Reverse cholesterol transport
UR - http://www.scopus.com/inward/record.url?scp=85139300830&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2022.112008
DO - 10.1016/j.foodres.2022.112008
M3 - Article
C2 - 36461234
AN - SCOPUS:85139300830
SN - 0963-9969
VL - 162
SP - 112008
JO - Food Research International
JF - Food Research International
M1 - 112008
ER -