Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice

Yijun Wang, Tiantian Liu, Yanmei Xie, Na Li, Yan Liu, Jiaqiang Wen, Man Zhang, Wanjie Feng, Jinbao Huang, Yuanxin Guo, Tufy Kabbas Junior, Dongxu Wang, Daniel Granato

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined the chemical compounds and bioactivity of the aqueous extract of Clitoria ternatea blue petals and investigated its beneficial effects in vivo on a mouse model of obesity and metabolic syndrome. The extract mainly contained flavonoids, and nine compounds were tentatively identified. Male C57BL/6J mice were either fed a standard diet (SD) or a high-fat, high-fructose diet (HFFD) for 16 weeks, and HFFD-fed animals were treated with 0.25%, 0.5%, and 2% (w/w) of the aqueous extract in drinking water. The aqueous extract ameliorated oxidative stress and inflammation mediators. Furthermore, the aqueous extract reduced plasma leptin, free fatty acid, low-density lipoprotein cholesterol levels and hepatic malondialdehyde content. The aqueous extract significantly reduced total cholesterol and ameliorated insulin resistance. The results demonstrated that the aqueous extract of C. ternatea blue petals contains bioactive anthocyanins that exert substantial hypolipidemic and anti-inflammatory effects by promoting reverse cholesterol transport in HFFD-fed mice.

Original languageEnglish
Article number112008
Pages (from-to)112008
JournalFood Research International
Volume162
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Anti-obesity
  • Flavonoids
  • Functional foods
  • In vivo study
  • Low-grade inflammation
  • Reactive oxygen species
  • Reverse cholesterol transport

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