Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela; B. Castro-Dominguez; A. Ziaee; B. Long; K. M. Ryan; G. Walker; E. J. O'Reilly

doi:10.1039/c9ce00060g

Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela, B. Castro-Dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker, E. J. O'Reilly

Department of Chemical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO₂ nano spray-drying, conventional spray-drying and solvent evaporation methods.

Original language	English
Pages (from-to)	2845-2848
Number of pages	4
Journal	CrystEngComm
Volume	21
Issue number	18
DOIs	https://doi.org/10.1039/c9ce00060g
Publication status	Published - 2019

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abstract = "The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.",

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AU - Padrela, L. M.

AU - Castro-Dominguez, B.

AU - Ziaee, A.

AU - Long, B.

AU - Ryan, K. M.

AU - Walker, G.

AU - O'Reilly, E. J.

PY - 2019

Y1 - 2019

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AB - The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

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U2 - 10.1039/c9ce00060g

DO - 10.1039/c9ce00060g

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JO - CrystEngComm

JF - CrystEngComm

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Co-crystal polymorphic control by nanodroplet and electrical confinement

Abstract

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