Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela; B. Castro-Dominguez; A. Ziaee; B. Long; K. M. Ryan; G. Walker; E. J. O'Reilly

doi:10.1039/c9ce00060g

Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela
, B. Castro-Dominguez
, A. Ziaee
, B. Long
, K. M. Ryan
, G. Walker
, E. J. O'Reilly

Research output: Contribution to journal › Article › peer-review

Abstract

The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO₂ nano spray-drying, conventional spray-drying and solvent evaporation methods.

Original language	English
Pages (from-to)	2845-2848
Number of pages	4
Journal	CrystEngComm
Volume	21
Issue number	18
DOIs	https://doi.org/10.1039/c9ce00060g
Publication status	Published - 2019

Access to Document

10.1039/c9ce00060g

Cite this

@article{383b085be1e74a4ea300a5377b49b21a,

title = "Co-crystal polymorphic control by nanodroplet and electrical confinement",

abstract = "The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.",

author = "Padrela, \{L. M.\} and B. Castro-Dominguez and A. Ziaee and B. Long and Ryan, \{K. M.\} and G. Walker and O'Reilly, \{E. J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9ce00060g",

language = "English",

volume = "21",

pages = "2845--2848",

journal = "CrystEngComm",

issn = "1466-8033",

number = "18",

}

TY - JOUR

T1 - Co-crystal polymorphic control by nanodroplet and electrical confinement

AU - Padrela, L. M.

AU - Castro-Dominguez, B.

AU - Ziaee, A.

AU - Long, B.

AU - Ryan, K. M.

AU - Walker, G.

AU - O'Reilly, E. J.

PY - 2019

Y1 - 2019

N2 - The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

AB - The polymorphic control of the co-crystal carbamazepine-saccharin (CBZ-SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ-SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

UR - https://www.scopus.com/pages/publications/85065502001

U2 - 10.1039/c9ce00060g

DO - 10.1039/c9ce00060g

M3 - Article

AN - SCOPUS:85065502001

SN - 1466-8033

VL - 21

SP - 2845

EP - 2848

JO - CrystEngComm

JF - CrystEngComm

IS - 18

ER -

Co-crystal polymorphic control by nanodroplet and electrical confinement

Abstract

Access to Document

Other files and links

Fingerprint

Cite this