TY - JOUR
T1 - Common genes and pathways involved in the response to stressful stimuli by astrocytes
T2 - A meta-analysis of genome-wide expression studies
AU - González-Giraldo, Yeimy
AU - Forero, Diego A.
AU - Barreto, George E.
AU - Aristizábal-Pachón, Andrés
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Astrocytes play pivotal roles in the brain and they become reactive under stress conditions. Here, we carried out, for the first time, an integrative meta-analysis of genome-wide expression profiling of astrocytes from human and mouse exposed to different stressful stimuli (hypoxia, infections by virus and bacteria, cytokines, ethanol, among others). We identified common differentially expressed genes and pathways in human and murine astrocytes. Our results showed that astrocytes induce expression of genes associated with stress response and immune system regulation when they are exposed to stressful stimuli, whereas genes related to neurogenesis are found as downregulated. Several of the identified genes showed to be important hubs in the protein-protein interaction analysis (TRAF2, CDC37 and PAX6). This work demonstrates that despite astrocytes are highly heterogeneous and complex, there are common gene expression signatures that can be triggered under distinct detrimental stimuli, which opens an opportunity for exploring other possible markers of reactivity.
AB - Astrocytes play pivotal roles in the brain and they become reactive under stress conditions. Here, we carried out, for the first time, an integrative meta-analysis of genome-wide expression profiling of astrocytes from human and mouse exposed to different stressful stimuli (hypoxia, infections by virus and bacteria, cytokines, ethanol, among others). We identified common differentially expressed genes and pathways in human and murine astrocytes. Our results showed that astrocytes induce expression of genes associated with stress response and immune system regulation when they are exposed to stressful stimuli, whereas genes related to neurogenesis are found as downregulated. Several of the identified genes showed to be important hubs in the protein-protein interaction analysis (TRAF2, CDC37 and PAX6). This work demonstrates that despite astrocytes are highly heterogeneous and complex, there are common gene expression signatures that can be triggered under distinct detrimental stimuli, which opens an opportunity for exploring other possible markers of reactivity.
KW - Astrocytes
KW - Convergence analysis
KW - Genome-wide expression profiling
KW - Reactivity
KW - Stress response
UR - http://www.scopus.com/inward/record.url?scp=85100040767&partnerID=8YFLogxK
U2 - 10.1016/j.ygeno.2021.01.008
DO - 10.1016/j.ygeno.2021.01.008
M3 - Article
C2 - 33485956
AN - SCOPUS:85100040767
SN - 0888-7543
VL - 113
SP - 669
EP - 680
JO - Genomics
JF - Genomics
IS - 2
ER -