Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles

Rakesh M. Patil, Nanasaheb D. Thorat, Prajkta B. Shete, Poonam A. Bedge, Shambala Gavde, Meghnad G. Joshi, Syed A.M. Tofail, Raghvendra A. Bohara

Research output: Contribution to journalReview articlepeer-review

Abstract

Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed.

Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalBiochemistry and Biophysics Reports
Volume13
DOIs
Publication statusPublished - Mar 2018

Keywords

  • Biomedical applications
  • Cellular alteration
  • SPIONs
  • Toxicity

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