Confounding effects in "a six-gene signature predicting breast cancer lung metastasis"

Aedín C. Culhane, John Quackenbush

Research output: Contribution to journalArticlepeer-review

Abstract

The majority of breast cancer deaths result from metastases rather than from direct effects of the primary tumor itself. Recently, Landemaine and colleagues described a six-gene signature purported to predict lung metastasis risk. They analyzed gene expression in 23 metastases from breast cancer patients (5 lung, 18 non-lung) identifying a 21-gene signature. Expression of 16 of these was analyzed in primary breast tumors from 72 patients with known outcome, and six were selected that were predictive of lung metastases: DSC2, TFCP2L1, UGT8, ITGB8, ANP32E, and FERMT1. Despite the value of such a signature, our analysis indicates that this analysis ignored potentially important confounding factors and that their signature is instead a surrogate for molecular subtype.

Original languageEnglish
Pages (from-to)7480-7485
Number of pages6
JournalCancer Research
Volume69
Issue number18
DOIs
Publication statusPublished - 2009
Externally publishedYes

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