Continuous, simultaneous cocrystallization and formulation of Theophylline and 4-Aminobenzoic acid pharmaceutical cocrystals using twin screw melt granulation

Rahamatullah Shaikh, Gavin M. Walker, Denise M. Croker

Research output: Contribution to journalArticlepeer-review

Abstract

In this work a cocrystal of Theophylline and 4Aminobenzoic acid was successfully produced and formulated using a hydrophilic binder with a novel continuous melt granulation approach. This melt granulation was followed with direct compression to generate oral solid dosage forms. The study revealed that the processing temperature, molecular weight of the binder and binder concentration were the most effective parameters for the production and formulation of high purity cocrystals. Superior tableting performance was observed for melt granulated cocrystals as compared with extruded cocrystals and pure theophylline. Moreover the prepared THP-4ABA melt granulated cocrystals were stable for 14 days (50 °C and 75% RH).

Original languageEnglish
Article number104981
Pages (from-to)104981
JournalEuropean Journal of Pharmaceutical Sciences
Volume137
DOIs
Publication statusPublished - 1 Sep 2019

Keywords

  • Continuous cocrystallization
  • Formulation
  • Material properties
  • Stability studies
  • Theophylline/4 aminobenzoic cocrystals
  • Twin screw melt granulation

Fingerprint

Dive into the research topics of 'Continuous, simultaneous cocrystallization and formulation of Theophylline and 4-Aminobenzoic acid pharmaceutical cocrystals using twin screw melt granulation'. Together they form a unique fingerprint.

Cite this