Abstract
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
Original language | English |
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Pages (from-to) | 5443-5446 |
Number of pages | 4 |
Journal | Infection and Immunity |
Volume | 68 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |