Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

J. M. Entenza; T. J. Foster; D. N. Eidhin; P. Vaudaux; P. Francioli; P. Moreillon

doi:10.1128/IAI.68.9.5443-5446.2000

Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

J. M. Entenza
, T. J. Foster
, D. N. Eidhin
, P. Vaudaux
, P. Francioli
, P. Moreillon

University of Lausanne

Research output: Contribution to journal › Article › peer-review

Abstract

Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.

Original language	English
Pages (from-to)	5443-5446
Number of pages	4
Journal	Infection and Immunity
Volume	68
Issue number	9
DOIs	https://doi.org/10.1128/IAI.68.9.5443-5446.2000
Publication status	Published - 2000
Externally published	Yes

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10.1128/IAI.68.9.5443-5446.2000

Cite this

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title = "Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus",

abstract = "Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.",

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AU - Entenza, J. M.

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AU - Vaudaux, P.

AU - Francioli, P.

AU - Moreillon, P.

PY - 2000

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AB - Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P > 0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P < 0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.

UR - https://www.scopus.com/pages/publications/0033857887

U2 - 10.1128/IAI.68.9.5443-5446.2000

DO - 10.1128/IAI.68.9.5443-5446.2000

M3 - Article

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AN - SCOPUS:0033857887

SN - 0019-9567

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JO - Infection and Immunity

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ER -

Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

Abstract

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