Contribution of the epstein-barr virus to the pathogenesis of hodgkin lymphoma

Paul Murray, Andrew Bell

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The morphology of the pathognomonic Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the B-cell origin of these cells was identified. In a proportion of cases, HRS cells harbour monoclonal forms of the B lymphotropic Epstein-Barr virus (EBV). This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV.

Original languageEnglish
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages287-313
Number of pages27
DOIs
Publication statusPublished - 2015
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume390
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

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