Controlling the Product Crystal Size Distribution by Strategic Application of Ultrasonication

Kiran A. Ramisetty, Åke C. Rasmuson

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, different strategies of ultrasonication (continuous, single pulse, and multiple pulse) are compared for control of the product crystal size distribution of three model API compounds: piracetam, paracetamol, and ibuprofen. Experiments have been performed on 0.5 and 3 L scales continuously recorded by FTIR and FBRM. Irrespective of the sonication operating mode, sonication in general produced smaller sized crystals with a more narrow size distribution in comparison to those for a normal cooling crystallization process. A multiple-pulse sonication mode, in particular, was capable of delivering more narrow size distributions. Sonication power per unit mass of solution does not appear to be a relevant scaling-up parameter.

Original languageEnglish
Pages (from-to)1697-1709
Number of pages13
JournalCrystal Growth and Design
Volume18
Issue number3
DOIs
Publication statusPublished - 7 Mar 2018

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