TY - JOUR
T1 - Controlling the Product Crystal Size Distribution by Strategic Application of Ultrasonication
AU - Ramisetty, Kiran A.
AU - Rasmuson, Åke C.
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/3/7
Y1 - 2018/3/7
N2 - In this work, different strategies of ultrasonication (continuous, single pulse, and multiple pulse) are compared for control of the product crystal size distribution of three model API compounds: piracetam, paracetamol, and ibuprofen. Experiments have been performed on 0.5 and 3 L scales continuously recorded by FTIR and FBRM. Irrespective of the sonication operating mode, sonication in general produced smaller sized crystals with a more narrow size distribution in comparison to those for a normal cooling crystallization process. A multiple-pulse sonication mode, in particular, was capable of delivering more narrow size distributions. Sonication power per unit mass of solution does not appear to be a relevant scaling-up parameter.
AB - In this work, different strategies of ultrasonication (continuous, single pulse, and multiple pulse) are compared for control of the product crystal size distribution of three model API compounds: piracetam, paracetamol, and ibuprofen. Experiments have been performed on 0.5 and 3 L scales continuously recorded by FTIR and FBRM. Irrespective of the sonication operating mode, sonication in general produced smaller sized crystals with a more narrow size distribution in comparison to those for a normal cooling crystallization process. A multiple-pulse sonication mode, in particular, was capable of delivering more narrow size distributions. Sonication power per unit mass of solution does not appear to be a relevant scaling-up parameter.
UR - http://www.scopus.com/inward/record.url?scp=85043302292&partnerID=8YFLogxK
U2 - 10.1021/acs.cgd.7b01619
DO - 10.1021/acs.cgd.7b01619
M3 - Article
AN - SCOPUS:85043302292
SN - 1528-7483
VL - 18
SP - 1697
EP - 1709
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 3
ER -