Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?

Daniel Torrente; Ricardo Cabezas; Marco Fidel Avila; Luis Miguel García-Segura; George E. Barreto; Rubem Carlos Araújo Guedes

doi:10.1016/j.neulet.2013.12.058

Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?

Daniel Torrente, Ricardo Cabezas, Marco Fidel Avila, Luis Miguel García-Segura, George E. Barreto, Rubem Carlos Araújo Guedes

Research output: Contribution to journal › Review article › peer-review

Abstract

Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.

Original language	English
Pages (from-to)	2-6
Number of pages	5
Journal	Neuroscience Letters
Volume	565
DOIs	https://doi.org/10.1016/j.neulet.2013.12.058
Publication status	Published - 17 Apr 2014
Externally published	Yes

Keywords

Astrocytes
CSD
Neurons
TBI

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neulet.2013.12.058

Cite this

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title = "Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?",

abstract = "Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.",

keywords = "Astrocytes, CSD, Neurons, TBI",

author = "Daniel Torrente and Ricardo Cabezas and Avila, {Marco Fidel} and Garc{\'i}a-Segura, {Luis Miguel} and Barreto, {George E.} and Guedes, {Rubem Carlos Ara{\'u}jo}",

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doi = "10.1016/j.neulet.2013.12.058",

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TY - JOUR

T1 - Cortical spreading depression in traumatic brain injuries

T2 - Is there a role for astrocytes?

AU - Torrente, Daniel

AU - Cabezas, Ricardo

AU - Avila, Marco Fidel

AU - García-Segura, Luis Miguel

AU - Barreto, George E.

AU - Guedes, Rubem Carlos Araújo

PY - 2014/4/17

Y1 - 2014/4/17

N2 - Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.

AB - Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.

KW - Astrocytes

KW - CSD

KW - Neurons

KW - TBI

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U2 - 10.1016/j.neulet.2013.12.058

DO - 10.1016/j.neulet.2013.12.058

M3 - Review article

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AN - SCOPUS:84897029443

SN - 0304-3940

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SP - 2

EP - 6

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?

Abstract

Keywords

UN SDGs

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