Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

David R. Weyna; Miranda L. Cheney; Ning Shan; Mazen Hanna; Łukasz Wojtas; Michael J. Zaworotko

doi:10.1039/c2ce06574f

Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

David R. Weyna, Miranda L. Cheney, Ning Shan, Mazen Hanna, Łukasz Wojtas, Michael J. Zaworotko

Research output: Contribution to journal › Article › peer-review

Abstract

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.

Original language	English
Pages (from-to)	2377-2380
Number of pages	4
Journal	CrystEngComm
Volume	14
Issue number	7
DOIs	https://doi.org/10.1039/c2ce06574f
Publication status	Published - 7 Apr 2012
Externally published	Yes

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title = "Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs",

abstract = "Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.",

author = "Weyna, {David R.} and Cheney, {Miranda L.} and Ning Shan and Mazen Hanna and {\L}ukasz Wojtas and Zaworotko, {Michael J.}",

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AU - Weyna, David R.

AU - Cheney, Miranda L.

AU - Shan, Ning

AU - Hanna, Mazen

AU - Wojtas, Łukasz

AU - Zaworotko, Michael J.

PY - 2012/4/7

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N2 - Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.

AB - Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.

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M3 - Article

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Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

Abstract

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