Crystal Shape Factors of Form I Paracetamol

Mayank Vashishtha; Juntao Li; Mahmoud Ranjbar; Srinivas Gadipelli; Paul R. Shearing; Gavin Walker; K. Vasanth Kumar

doi:10.1021/acs.cgd.5c00005

Crystal Shape Factors of Form I Paracetamol

Mayank Vashishtha
, Juntao Li
, Mahmoud Ranjbar
, Srinivas Gadipelli
, Paul R. Shearing
, Gavin Walker
, K. Vasanth Kumar

Department of Chemical Sciences

University College London
University of Oxford
Bernal Institute
University of Limerick
University of Surrey

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, we report the new protocols that are developed to determine the shape factors of Form I paracetamol crystals using a combination of techniques that rely on the state-of-the-art X-ray computed tomography and Morphologi G3. The determined shape factors successfully predicted the crystal growth rate of paracetamol in 2-propanol and the length of the crystals growing in the supersaturated solution.

Original language	English
Pages (from-to)	2784-2791
Number of pages	8
Journal	Crystal Growth and Design
Volume	25
Issue number	9
DOIs	https://doi.org/10.1021/acs.cgd.5c00005
Publication status	Published - 7 May 2025

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10.1021/acs.cgd.5c00005

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title = "Crystal Shape Factors of Form I Paracetamol",

abstract = "In this work, we report the new protocols that are developed to determine the shape factors of Form I paracetamol crystals using a combination of techniques that rely on the state-of-the-art X-ray computed tomography and Morphologi G3. The determined shape factors successfully predicted the crystal growth rate of paracetamol in 2-propanol and the length of the crystals growing in the supersaturated solution.",

author = "Mayank Vashishtha and Juntao Li and Mahmoud Ranjbar and Srinivas Gadipelli and Shearing, \{Paul R.\} and Gavin Walker and Kumar, \{K. Vasanth\}",

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AU - Li, Juntao

AU - Ranjbar, Mahmoud

AU - Gadipelli, Srinivas

AU - Shearing, Paul R.

AU - Walker, Gavin

AU - Kumar, K. Vasanth

PY - 2025/5/7

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AB - In this work, we report the new protocols that are developed to determine the shape factors of Form I paracetamol crystals using a combination of techniques that rely on the state-of-the-art X-ray computed tomography and Morphologi G3. The determined shape factors successfully predicted the crystal growth rate of paracetamol in 2-propanol and the length of the crystals growing in the supersaturated solution.

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Crystal Shape Factors of Form I Paracetamol

Abstract

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