Crystallization kinetics of ampicillin

M. Ottens; B. Lebreton; M. Zomerdijk; M. P.W.M. Rijkers; O. S.L. Bruinsma; L. A.M. Van Der Wielen

doi:10.1021/ie0101238

Crystallization kinetics of ampicillin

M. Ottens, B. Lebreton, M. Zomerdijk, M. P.W.M. Rijkers, O. S.L. Bruinsma, L. A.M. Van Der Wielen

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Abstract

The first results regarding the crystallization kinetics of the pure semisynthetic β-lactam antibiotic (SSA) ampicillin in water are presented. The experimentally obtained results at pH = 5 and T = 298 K are described well by the population-based crystallization model presented in this paper. The nucleation rate J (# m^-3 s^-1) is related to the supersaturation ratio of ampicillin S by J = 2 × 10⁷ exp[-3.383/(ln(S))²]. The surface energy γ of creating a nucleus of ampicillin molecules therefore equals 5.83 mJ m^-2. The growth rate G (m s^-1) is determined with a newly developed adapted single-crystal growth rate analysis method and is related to the supersaturation ratio of ampicillin S by G = 4.57 × 10^-8(S - 1)^1.72.

Original language	English
Pages (from-to)	4821-4827
Number of pages	7
Journal	Industrial and Engineering Chemistry Research
Volume	40
Issue number	22
DOIs	https://doi.org/10.1021/ie0101238
Publication status	Published - 31 Oct 2001
Externally published	Yes

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title = "Crystallization kinetics of ampicillin",

abstract = "The first results regarding the crystallization kinetics of the pure semisynthetic β-lactam antibiotic (SSA) ampicillin in water are presented. The experimentally obtained results at pH = 5 and T = 298 K are described well by the population-based crystallization model presented in this paper. The nucleation rate J (# m-3 s-1) is related to the supersaturation ratio of ampicillin S by J = 2 × 107 exp[-3.383/(ln(S))2]. The surface energy γ of creating a nucleus of ampicillin molecules therefore equals 5.83 mJ m-2. The growth rate G (m s-1) is determined with a newly developed adapted single-crystal growth rate analysis method and is related to the supersaturation ratio of ampicillin S by G = 4.57 × 10-8(S - 1)1.72.",

author = "M. Ottens and B. Lebreton and M. Zomerdijk and Rijkers, {M. P.W.M.} and Bruinsma, {O. S.L.} and {Van Der Wielen}, {L. A.M.}",

year = "2001",

month = oct,

day = "31",

doi = "10.1021/ie0101238",

language = "English",

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journal = "Industrial and Engineering Chemistry Research",

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TY - JOUR

T1 - Crystallization kinetics of ampicillin

AU - Ottens, M.

AU - Lebreton, B.

AU - Zomerdijk, M.

AU - Rijkers, M. P.W.M.

AU - Bruinsma, O. S.L.

AU - Van Der Wielen, L. A.M.

PY - 2001/10/31

Y1 - 2001/10/31

N2 - The first results regarding the crystallization kinetics of the pure semisynthetic β-lactam antibiotic (SSA) ampicillin in water are presented. The experimentally obtained results at pH = 5 and T = 298 K are described well by the population-based crystallization model presented in this paper. The nucleation rate J (# m-3 s-1) is related to the supersaturation ratio of ampicillin S by J = 2 × 107 exp[-3.383/(ln(S))2]. The surface energy γ of creating a nucleus of ampicillin molecules therefore equals 5.83 mJ m-2. The growth rate G (m s-1) is determined with a newly developed adapted single-crystal growth rate analysis method and is related to the supersaturation ratio of ampicillin S by G = 4.57 × 10-8(S - 1)1.72.

AB - The first results regarding the crystallization kinetics of the pure semisynthetic β-lactam antibiotic (SSA) ampicillin in water are presented. The experimentally obtained results at pH = 5 and T = 298 K are described well by the population-based crystallization model presented in this paper. The nucleation rate J (# m-3 s-1) is related to the supersaturation ratio of ampicillin S by J = 2 × 107 exp[-3.383/(ln(S))2]. The surface energy γ of creating a nucleus of ampicillin molecules therefore equals 5.83 mJ m-2. The growth rate G (m s-1) is determined with a newly developed adapted single-crystal growth rate analysis method and is related to the supersaturation ratio of ampicillin S by G = 4.57 × 10-8(S - 1)1.72.

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U2 - 10.1021/ie0101238

DO - 10.1021/ie0101238

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SP - 4821

EP - 4827

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 22

ER -

Crystallization kinetics of ampicillin

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