TY - JOUR
T1 - Curcumin
T2 - a phytochemical modulator of estrogens and androgens in tumors of the reproductive system
AU - Mohajeri, Mohammad
AU - Bianconi, Vanessa
AU - Ávila-Rodriguez, Marco Fidel
AU - Barreto, George E.
AU - Jamialahmadi, Tannaz
AU - Pirro, Matteo
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/6
Y1 - 2020/6
N2 - Curcumin (Cur) is an active derivative extracted from turmeric which exerts a wide range of interactions with biomolecules through complex signaling pathways. Cur has been extensively shown to possess potential antitumor properties. In addition, there is growing body of evidence suggesting that Cur may exert potential anti-estrogen and anti-androgen activity. In vitro and in vivo studies suggest that anticancer properties of Cur against tumors affecting the reproductive system in females and males may be underlied by the Cur-mediated inhibition of androgen and estrogen signaling pathways. In this review we examine various studies assessing the crosstalk between Cur and both androgen and estrogen hormonal activity. Also, we discuss the potential chemopreventive and antitumor role of Cur in the most prevalent cancers affecting the reproductive system in females and males.
AB - Curcumin (Cur) is an active derivative extracted from turmeric which exerts a wide range of interactions with biomolecules through complex signaling pathways. Cur has been extensively shown to possess potential antitumor properties. In addition, there is growing body of evidence suggesting that Cur may exert potential anti-estrogen and anti-androgen activity. In vitro and in vivo studies suggest that anticancer properties of Cur against tumors affecting the reproductive system in females and males may be underlied by the Cur-mediated inhibition of androgen and estrogen signaling pathways. In this review we examine various studies assessing the crosstalk between Cur and both androgen and estrogen hormonal activity. Also, we discuss the potential chemopreventive and antitumor role of Cur in the most prevalent cancers affecting the reproductive system in females and males.
KW - androgen
KW - cancer
KW - curcumin
KW - estrogen
KW - hormonal activity
UR - http://www.scopus.com/inward/record.url?scp=85082738865&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2020.104765
DO - 10.1016/j.phrs.2020.104765
M3 - Review article
C2 - 32217147
AN - SCOPUS:85082738865
SN - 1043-6618
VL - 156
SP - -
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 104765
ER -
