Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

Shabnam Radbakhsh; George E. Barreto; Abigail R. Bland; Amirhossein Sahebkar

doi:10.1002/biof.1735

Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

Shabnam Radbakhsh
, George E. Barreto
, Abigail R. Bland
, Amirhossein Sahebkar

Research output: Contribution to journal › Review article › peer-review

Abstract

Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.

Original language	English
Pages (from-to)	570-586
Number of pages	17
Journal	BioFactors
Volume	47
Issue number	4
DOIs	https://doi.org/10.1002/biof.1735
Publication status	Published - 1 Jul 2021

Keywords

amyloid-beta (Aβ) plaque
amyloidosis
curcumin
islet amyloid polypeptide (IAPP)
α-Synuclein fibrillar

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/biof.1735

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title = "Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes",

abstract = "Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.",

keywords = "amyloid-beta (Aβ) plaque, amyloidosis, curcumin, islet amyloid polypeptide (IAPP), α-Synuclein fibrillar",

author = "Shabnam Radbakhsh and Barreto, \{George E.\} and Bland, \{Abigail R.\} and Amirhossein Sahebkar",

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year = "2021",

month = jul,

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doi = "10.1002/biof.1735",

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T1 - Curcumin

T2 - A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

AU - Radbakhsh, Shabnam

AU - Barreto, George E.

AU - Bland, Abigail R.

AU - Sahebkar, Amirhossein

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.

AB - Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.

KW - amyloid-beta (Aβ) plaque

KW - amyloidosis

KW - curcumin

KW - islet amyloid polypeptide (IAPP)

KW - α-Synuclein fibrillar

UR - https://www.scopus.com/pages/publications/85104802488

U2 - 10.1002/biof.1735

DO - 10.1002/biof.1735

M3 - Review article

C2 - 33893674

AN - SCOPUS:85104802488

SN - 0951-6433

VL - 47

SP - 570

EP - 586

JO - BioFactors

JF - BioFactors

IS - 4

ER -

Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

Abstract

Keywords

UN SDGs

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