TY - JOUR
T1 - Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning
AU - Aramouni, Nicolas Abdel Karim
AU - Steiner-Browne, Marina
AU - Mouras, Rabah
N1 - Publisher Copyright:
© 2023
PY - 2023/6
Y1 - 2023/6
N2 - This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20% vol) must be assessed for API solubility and suitability for CIP applications.
AB - This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20% vol) must be assessed for API solubility and suitability for CIP applications.
KW - Cleaning
KW - Cyrene
KW - Pharmaceuticals
KW - Solubility
KW - Sustainability
UR - http://www.scopus.com/inward/record.url?scp=85161648647&partnerID=8YFLogxK
U2 - 10.1016/j.scp.2023.101149
DO - 10.1016/j.scp.2023.101149
M3 - Article
AN - SCOPUS:85161648647
SN - 2352-5541
VL - 33
JO - Sustainable Chemistry and Pharmacy
JF - Sustainable Chemistry and Pharmacy
M1 - 101149
ER -