Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning

Nicolas Abdel Karim Aramouni; Marina Steiner-Browne; Rabah Mouras

doi:10.1016/j.scp.2023.101149

Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning

Nicolas Abdel Karim Aramouni
, Marina Steiner-Browne
, Rabah Mouras

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20% vol) must be assessed for API solubility and suitability for CIP applications.

Original language	English
Article number	101149
Journal	Sustainable Chemistry and Pharmacy
Volume	33
DOIs	https://doi.org/10.1016/j.scp.2023.101149
Publication status	Published - Jun 2023

Keywords

Cleaning
Cyrene
Pharmaceuticals
Solubility
Sustainability

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10.1016/j.scp.2023.101149

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title = "Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning",

abstract = "This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20\% vol) must be assessed for API solubility and suitability for CIP applications.",

keywords = "Cleaning, Cyrene, Pharmaceuticals, Solubility, Sustainability",

author = "Aramouni, \{Nicolas Abdel Karim\} and Marina Steiner-Browne and Rabah Mouras",

note = "Publisher Copyright: {\textcopyright} 2023",

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doi = "10.1016/j.scp.2023.101149",

language = "English",

volume = "33",

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T1 - Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning

AU - Aramouni, Nicolas Abdel Karim

AU - Steiner-Browne, Marina

AU - Mouras, Rabah

PY - 2023/6

Y1 - 2023/6

N2 - This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20% vol) must be assessed for API solubility and suitability for CIP applications.

AB - This work explores the use of cyrene as a green solvent to improve the cleaning performance on Islatravir, Doravirine and Olanzapine, which are challenging drugs to clean. Cyrene addition showed an improvement in aqueous and methanolic solubility, and ternary cyrene blends showed high solubility at high cyrene concentration, which did not directly translate into a reduction in cleaning time. The presence of cyrene and its geminal diol form reduced the API surface concentration after cleaning, thus improving the dissolution of the bound API layer. Cyrene was efficiently removed by water and left low residues. Higher cyrene concentrations (>20% vol) must be assessed for API solubility and suitability for CIP applications.

KW - Cleaning

KW - Cyrene

KW - Pharmaceuticals

KW - Solubility

KW - Sustainability

UR - https://www.scopus.com/pages/publications/85161648647

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DO - 10.1016/j.scp.2023.101149

M3 - Article

AN - SCOPUS:85161648647

SN - 2352-5541

VL - 33

JO - Sustainable Chemistry and Pharmacy

JF - Sustainable Chemistry and Pharmacy

M1 - 101149

ER -

Cyrene as a greener alternative to harmful solvents used in pharmaceutical cleaning

Abstract

Keywords

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