TY - JOUR
T1 - Delayed ghrelin suppression following oral glucose tolerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls
AU - O'Gorman, Clodagh S.
AU - Simoneau-Roy, Judith
AU - Pencharz Mb, Paul
AU - Adeli, Khosrow
AU - Hamilton, Jill
PY - 2011/8
Y1 - 2011/8
N2 - Ghrelin, released from the stomach, acts at the hypothalamus and is associated with initiation of food intake. We hypothesised that patients with craniopharyngioma and hypothalamic obesity (CRHO) would have ghrelin abnormalities. Fifteen CRHO patients and 15 BMI-matched controls underwent oral glucose tolerance test with dynamic ghrelin measurement. From 030 minutes, ghrelin (pg/ml) decreased less (43.4 ± 38.8 vs. 70.8 ± 35.8, p < 0.05) and insulin (pmol/l) increased more (1 669.2 ± 861.7 vs. 1 049.1 ± 560.4, p = 0.04) in CRHO compared with controls, respectively. Insulin area-under-the-curve was a weak negative predictor of the 030 minutes ghrelin decrease (r2 = 0.29, p = 0.02). Delayed ghrelin suppression may contribute to obesity in CRHO.
AB - Ghrelin, released from the stomach, acts at the hypothalamus and is associated with initiation of food intake. We hypothesised that patients with craniopharyngioma and hypothalamic obesity (CRHO) would have ghrelin abnormalities. Fifteen CRHO patients and 15 BMI-matched controls underwent oral glucose tolerance test with dynamic ghrelin measurement. From 030 minutes, ghrelin (pg/ml) decreased less (43.4 ± 38.8 vs. 70.8 ± 35.8, p < 0.05) and insulin (pmol/l) increased more (1 669.2 ± 861.7 vs. 1 049.1 ± 560.4, p = 0.04) in CRHO compared with controls, respectively. Insulin area-under-the-curve was a weak negative predictor of the 030 minutes ghrelin decrease (r2 = 0.29, p = 0.02). Delayed ghrelin suppression may contribute to obesity in CRHO.
KW - Craniopharyngioma
KW - Ghrelin
KW - Hypothalamic obesity
KW - Satiety hormones
UR - http://www.scopus.com/inward/record.url?scp=79960341957&partnerID=8YFLogxK
U2 - 10.3109/17477166.2010.519388
DO - 10.3109/17477166.2010.519388
M3 - Article
C2 - 21050078
AN - SCOPUS:79960341957
SN - 1747-7166
VL - 6
SP - 285
EP - 288
JO - International Journal of Pediatric Obesity
JF - International Journal of Pediatric Obesity
IS - 3-4
ER -