Delayed ghrelin suppression following oral glucose tolerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls

Clodagh S. O'Gorman, Judith Simoneau-Roy, Paul Pencharz Mb, Khosrow Adeli, Jill Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Ghrelin, released from the stomach, acts at the hypothalamus and is associated with initiation of food intake. We hypothesised that patients with craniopharyngioma and hypothalamic obesity (CRHO) would have ghrelin abnormalities. Fifteen CRHO patients and 15 BMI-matched controls underwent oral glucose tolerance test with dynamic ghrelin measurement. From 030 minutes, ghrelin (pg/ml) decreased less (43.4 ± 38.8 vs. 70.8 ± 35.8, p < 0.05) and insulin (pmol/l) increased more (1 669.2 ± 861.7 vs. 1 049.1 ± 560.4, p = 0.04) in CRHO compared with controls, respectively. Insulin area-under-the-curve was a weak negative predictor of the 030 minutes ghrelin decrease (r2 = 0.29, p = 0.02). Delayed ghrelin suppression may contribute to obesity in CRHO.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalInternational Journal of Pediatric Obesity
Volume6
Issue number3-4
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

Keywords

  • Craniopharyngioma
  • Ghrelin
  • Hypothalamic obesity
  • Satiety hormones

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