Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

Chinmay A. Shukla; Bantu Udaykumar; Y. Saisivanarayana; Arsh Ismaili; T. Haripriya; Manish M. Shinde; Srinivasan Neti; Maheshkumar Uppada; Vishnuvardhana Eda; Saikat Sen; Srinivas Oruganti

doi:10.1007/s41981-021-00186-x

Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

Chinmay A. Shukla
, Bantu Udaykumar
, Y. Saisivanarayana
, Arsh Ismaili
, T. Haripriya
, Manish M. Shinde
, Srinivasan Neti
, Maheshkumar Uppada
, Vishnuvardhana Eda
, Saikat Sen
, Srinivas Oruganti

University of Hyderabad

Research output: Contribution to journal › Article › peer-review

Abstract

A green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85% isolated yield and purity >99% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Journal	Journal of Flow Chemistry
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s41981-021-00186-x
Publication status	Published - Mar 2022
Externally published	Yes

Keywords

Continuous flow
Green chemistry
Hydrogen peroxide
Nutraceuticals
Oxidation
Sulfones

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10.1007/s41981-021-00186-x

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title = "Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow",

abstract = "A green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85\% isolated yield and purity >99\% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Continuous flow, Green chemistry, Hydrogen peroxide, Nutraceuticals, Oxidation, Sulfones",

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doi = "10.1007/s41981-021-00186-x",

language = "English",

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T1 - Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

AU - Shukla, Chinmay A.

AU - Udaykumar, Bantu

AU - Saisivanarayana, Y.

AU - Ismaili, Arsh

AU - Haripriya, T.

AU - Shinde, Manish M.

AU - Neti, Srinivasan

AU - Uppada, Maheshkumar

AU - Eda, Vishnuvardhana

AU - Sen, Saikat

AU - Oruganti, Srinivas

PY - 2022/3

Y1 - 2022/3

N2 - A green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85% isolated yield and purity >99% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output. Graphical abstract: [Figure not available: see fulltext.]

AB - A green and potentially scalable continuous flow synthesis of a popular sulfone containing nutraceutical, methylsulfonylmethane (MSM), has been demonstrated in a Vapourtec tubular reactor platform via metal catalyst-free hydrogen peroxide mediated oxidation of dimethyl sulfoxide. Under optimized conditions, MSM could be obtained in >85% isolated yield and purity >99% with a productivity of 23.6 g/h simply by cooling the reaction mixture collected at the output. Graphical abstract: [Figure not available: see fulltext.]

KW - Continuous flow

KW - Green chemistry

KW - Hydrogen peroxide

KW - Nutraceuticals

KW - Oxidation

KW - Sulfones

UR - https://www.scopus.com/pages/publications/85111880913

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DO - 10.1007/s41981-021-00186-x

M3 - Article

AN - SCOPUS:85111880913

SN - 2062-249X

VL - 12

JO - Journal of Flow Chemistry

JF - Journal of Flow Chemistry

IS - 1

ER -

Delineating a green, catalyst free synthesis of a popular nutraceutical methylsulfonylmethane (MSM) in continuous flow

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Keywords

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