Demystified . . . Human endogenous retroviruses

P. N. Nelson; P. R. Carnegie; J. Martin; H. Davari Ejtehadi; P. Hooley; D. Roden; S. Rowland-Jones; P. Warren; J. Astley; P. G. Murray

doi:10.1136/mp.56.1.11

Demystified . . . Human endogenous retroviruses

P. N. Nelson, P. R. Carnegie, J. Martin, H. Davari Ejtehadi, P. Hooley, D. Roden, S. Rowland-Jones, P. Warren, J. Astley, P. G. Murray

Research output: Contribution to journal › Review article › peer-review

Abstract

Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	Journal of Clinical Pathology - Molecular Pathology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1136/mp.56.1.11
Publication status	Published - Feb 2003
Externally published	Yes

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abstract = "Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.",

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T1 - Demystified . . . Human endogenous retroviruses

AU - Nelson, P. N.

AU - Carnegie, P. R.

AU - Martin, J.

AU - Davari Ejtehadi, H.

AU - Hooley, P.

AU - Roden, D.

AU - Rowland-Jones, S.

AU - Warren, P.

AU - Astley, J.

AU - Murray, P. G.

PY - 2003/2

Y1 - 2003/2

N2 - Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

AB - Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

UR - http://www.scopus.com/inward/record.url?scp=0037317086&partnerID=8YFLogxK

U2 - 10.1136/mp.56.1.11

DO - 10.1136/mp.56.1.11

M3 - Review article

C2 - 12560456

AN - SCOPUS:0037317086

SN - 1366-8714

VL - 56

SP - 11

EP - 18

JO - Journal of Clinical Pathology - Molecular Pathology

JF - Journal of Clinical Pathology - Molecular Pathology

IS - 1

ER -

Demystified . . . Human endogenous retroviruses

Abstract

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