Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment

Adriana J. Michielsen; Elizabeth J. Ryan; Jacintha N. O'Sullivan

doi:10.4161/onci.21318

Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment

Adriana J. Michielsen
, Elizabeth J. Ryan
, Jacintha N. O'Sullivan

Trinity College Dublin, St James's Hospital
University College Dublin

Research output: Contribution to journal › Comment/debate

Abstract

We demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor microenvironment on infiltrating immune cells may offer an avenue for the discovery of biomarkers to guide the use of bevacizumab.

Original language	English
Pages (from-to)	1445-1447
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	8
DOIs	https://doi.org/10.4161/onci.21318
Publication status	Published - 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bevacizumab
Colorectal cancer
Dendritic cells
Tumor microenvironment

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10.4161/onci.21318

Cite this

@article{74e4f1e8f006491690ce95737c1c9f7f,

title = "Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment",

abstract = "We demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor microenvironment on infiltrating immune cells may offer an avenue for the discovery of biomarkers to guide the use of bevacizumab.",

keywords = "Bevacizumab, Colorectal cancer, Dendritic cells, Tumor microenvironment",

author = "Michielsen, \{Adriana J.\} and Ryan, \{Elizabeth J.\} and O'Sullivan, \{Jacintha N.\}",

year = "2012",

doi = "10.4161/onci.21318",

language = "English",

volume = "1",

pages = "1445--1447",

journal = "OncoImmunology",

issn = "2162-4011",

number = "8",

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TY - JOUR

T1 - Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment

AU - Michielsen, Adriana J.

AU - Ryan, Elizabeth J.

AU - O'Sullivan, Jacintha N.

PY - 2012

Y1 - 2012

N2 - We demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor microenvironment on infiltrating immune cells may offer an avenue for the discovery of biomarkers to guide the use of bevacizumab.

AB - We demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor microenvironment on infiltrating immune cells may offer an avenue for the discovery of biomarkers to guide the use of bevacizumab.

KW - Bevacizumab

KW - Colorectal cancer

KW - Dendritic cells

KW - Tumor microenvironment

UR - https://www.scopus.com/pages/publications/84876872556

U2 - 10.4161/onci.21318

DO - 10.4161/onci.21318

M3 - Comment/debate

AN - SCOPUS:84876872556

SN - 2162-4011

VL - 1

SP - 1445

EP - 1447

JO - OncoImmunology

JF - OncoImmunology

IS - 8

ER -

Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment

Abstract

UN SDGs

Keywords

Access to Document

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