Abstract
The results of this study show that bilateral olfactory bulbectomy is associated with a suppression of neutrophil phagocytosis, an effect which is qualitatively similar to that found in untreated depressed patients. The suppression of neutrophil phagocytosis in the bulbectomized rat is reversed by chronic desipramine treatment suggesting that the change is a state marker of the brain lesion. These findings support the view that the limbic regions of the rat brain have a regulatory role in programming the activities of the immune system. In addition, it provides evidence in favour of the bulbectomized rat as a model of depression.
| Original language | English |
|---|---|
| Pages (from-to) | 267-268 |
| Number of pages | 2 |
| Journal | Medical Science Research |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - 1987 |
| Externally published | Yes |