Design of bioactive glasses as matrices for tissue engineering

K. E. Wallace, R. G. Hill, J. T. Pembroke, C. J. Brown, P. V. Hatten

Research output: Contribution to conferencePaperpeer-review

Abstract

The preparation of bioactive glasses, which have osteoconductive properties for using as scaffolds in tissue engineering was investigated. Five glasses with different composition and a network connectivity of 2.04 were produced and studied in vitro using a rat osteosarcoma cell line. The MTT and total protein determinations were carried out and the influence of conditioning of biological response was examined. The in vitro study revealed that cytotoxicity was significantly reduced for X=0, 0.4. Conditioning was found to improve the biological response in the case of the samples of intermediate Na2O content. The study indicates that it is possible to design bioactive glasses for tissue engineering applications.

Original languageEnglish
Pages77
Number of pages1
Publication statusPublished - 2000
EventSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom
Duration: 16 Jul 200019 Jul 2000

Conference

ConferenceSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
Country/TerritoryUnited Kingdom
CityYork
Period16/07/0019/07/00

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