Design of bioactive glasses as matrices for tissue engineering

K. E. Wallace; R. G. Hill; J. T. Pembroke; C. J. Brown; P. V. Hatten

Design of bioactive glasses as matrices for tissue engineering

K. E. Wallace
, R. G. Hill
, J. T. Pembroke
, C. J. Brown
, P. V. Hatten

University of Limerick
Imperial College London
University of Sheffield

Research output: Contribution to conference › Paper › peer-review

Abstract

The preparation of bioactive glasses, which have osteoconductive properties for using as scaffolds in tissue engineering was investigated. Five glasses with different composition and a network connectivity of 2.04 were produced and studied in vitro using a rat osteosarcoma cell line. The MTT and total protein determinations were carried out and the influence of conditioning of biological response was examined. The in vitro study revealed that cytotoxicity was significantly reduced for X=0, 0.4. Conditioning was found to improve the biological response in the case of the samples of intermediate Na₂O content. The study indicates that it is possible to design bioactive glasses for tissue engineering applications.

Original language	English
Pages	77
Number of pages	1
Publication status	Published - 2000
Event	Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom Duration: 16 Jul 2000 → 19 Jul 2000

Conference

Conference	Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
Country/Territory	United Kingdom
City	York
Period	16/07/00 → 19/07/00

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@conference{2a90861349b446619e13e3b36213002a,

title = "Design of bioactive glasses as matrices for tissue engineering",

abstract = "The preparation of bioactive glasses, which have osteoconductive properties for using as scaffolds in tissue engineering was investigated. Five glasses with different composition and a network connectivity of 2.04 were produced and studied in vitro using a rat osteosarcoma cell line. The MTT and total protein determinations were carried out and the influence of conditioning of biological response was examined. The in vitro study revealed that cytotoxicity was significantly reduced for X=0, 0.4. Conditioning was found to improve the biological response in the case of the samples of intermediate Na2O content. The study indicates that it is possible to design bioactive glasses for tissue engineering applications.",

author = "Wallace, \{K. E.\} and Hill, \{R. G.\} and Pembroke, \{J. T.\} and Brown, \{C. J.\} and Hatten, \{P. V.\}",

year = "2000",

language = "English",

pages = "77",

note = "Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling ; Conference date: 16-07-2000 Through 19-07-2000",

}

Design of bioactive glasses as matrices for tissue engineering. / Wallace, K. E.; Hill, R. G.; Pembroke, J. T. et al.
2000. 77 Paper presented at Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Design of bioactive glasses as matrices for tissue engineering

AU - Wallace, K. E.

AU - Hill, R. G.

AU - Pembroke, J. T.

AU - Brown, C. J.

AU - Hatten, P. V.

PY - 2000

Y1 - 2000

N2 - The preparation of bioactive glasses, which have osteoconductive properties for using as scaffolds in tissue engineering was investigated. Five glasses with different composition and a network connectivity of 2.04 were produced and studied in vitro using a rat osteosarcoma cell line. The MTT and total protein determinations were carried out and the influence of conditioning of biological response was examined. The in vitro study revealed that cytotoxicity was significantly reduced for X=0, 0.4. Conditioning was found to improve the biological response in the case of the samples of intermediate Na2O content. The study indicates that it is possible to design bioactive glasses for tissue engineering applications.

AB - The preparation of bioactive glasses, which have osteoconductive properties for using as scaffolds in tissue engineering was investigated. Five glasses with different composition and a network connectivity of 2.04 were produced and studied in vitro using a rat osteosarcoma cell line. The MTT and total protein determinations were carried out and the influence of conditioning of biological response was examined. The in vitro study revealed that cytotoxicity was significantly reduced for X=0, 0.4. Conditioning was found to improve the biological response in the case of the samples of intermediate Na2O content. The study indicates that it is possible to design bioactive glasses for tissue engineering applications.

UR - https://www.scopus.com/pages/publications/18644372786

M3 - Paper

AN - SCOPUS:18644372786

SP - 77

T2 - Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Y2 - 16 July 2000 through 19 July 2000

ER -

Design of bioactive glasses as matrices for tissue engineering

Abstract

Conference

UN SDGs

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