Development and validation of a two-dimensional population balance model for a supercritical CO2 antisolvent batch crystallization process

Indu Muthancheri, Barry Long, Kevin M. Ryan, Luis Padrela, Rohit Ramachandran

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, a two-dimensional population balance model with solvent removal kinetics has been developed to predict the dynamic behavior of carbamazepine form II crystals produced by a supercritical CO2 antisolvent batch crystallization process. The model was simulated and validated using experimental crystal size distribution data (CSD). The model was able to accurately predict the behavior of CSD with a change in process operating conditions. The model was also applied to study the time evolution of aspect ratio, average crystal length, and solute concentration in the solution. Finally, solvent removal kinetics were modeled to evaluate the solvent content and drying temperature of the drying gas during the solvent removal process. The developed mathematical model and the presented results suggest the ability of the discussed approach to make suitable model predictions, which can significantly reduce the number of experimental trials required for process design, optimization, and control.

Original languageEnglish
Pages (from-to)3191-3204
Number of pages14
JournalAdvanced Powder Technology
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • CO antisolvent crystallization
  • crystal aggregation
  • crystal growth
  • Population balance model

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