Development of tip-enhanced optical spectroscopy for biological applications: A review

Alistair P.D. Elfick; Andrew R. Downes; Rabah Mouras

doi:10.1007/s00216-009-3223-9

Development of tip-enhanced optical spectroscopy for biological applications: A review

Alistair P.D. Elfick, Andrew R. Downes, Rabah Mouras

University of Edinburgh

Research output: Contribution to journal › Review article › peer-review

Abstract

Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.

Original language	English
Pages (from-to)	45-52
Number of pages	8
Journal	Analytical and Bioanalytical Chemistry
Volume	396
Issue number	1
DOIs	https://doi.org/10.1007/s00216-009-3223-9
Publication status	Published - Jan 2010
Externally published	Yes

Keywords

Biological samples
Near-field
Raman
TERS
Tip-enhanced CARS

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10.1007/s00216-009-3223-9

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abstract = "Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.",

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author = "Elfick, {Alistair P.D.} and Downes, {Andrew R.} and Rabah Mouras",

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AB - Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.

KW - Biological samples

KW - Near-field

KW - Raman

KW - TERS

KW - Tip-enhanced CARS

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JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

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ER -

Development of tip-enhanced optical spectroscopy for biological applications: A review

Abstract

Keywords

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