TY - JOUR
T1 - Dietary interventions with or without omega-3 supplementation for the management of rheumatoid arthritis
T2 - a systematic review protocol
AU - Raad, Tala
AU - George, Elena
AU - Griffin, Anne
AU - Larkin, Louise
AU - Fraser, Alexander
AU - Kennedy, Norelee
AU - Tierney, Audrey C.
N1 - Publisher Copyright:
Copyright: © 2020 Raad T et al.
PY - 2020
Y1 - 2020
N2 - Background: Rheumatoid arthritis (RA) is an autoimmune disease characterised by swollen and painful joints. It is hypothesised that changes in lifestyle factors such as consuming a healthier diet may reduce the severity of RA symptoms. People living with RA commonly make alterations to their dietary intake with the hope of improving their symptoms. This systematic review aims to discuss the effects of dietary interventions with and without omega-3 supplementation for the management of rheumatoid arthritis. Methods: A systematic review of randomised controlled trials (RCTs) and non-randomised controlled trials (NRCTs) will be conducted. MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register) and CINAHL will be searched from inception without using date restrictions. Primary outcomes will include measures of disease activity, inflammation and quality of life among adults living with RA. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the methodological appraisal of the studies will be assessed independently by two different reviewers (TR and AG) using the Cochrane Risk-of-Bias Tool for RCTs, and Risk-of-Bias In Non-Randomised Studies Tool for NRCTs. Ethics and dissemination: Ethical approval is not required for this systematic review. Only publically available data from previously published studies will be used. The findings of this systematic review will be submitted for publication in a peer-reviewed journal and presented at relevant conferences. PROSPERO registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020147415 CRD42020147415 (11/02/2020).
AB - Background: Rheumatoid arthritis (RA) is an autoimmune disease characterised by swollen and painful joints. It is hypothesised that changes in lifestyle factors such as consuming a healthier diet may reduce the severity of RA symptoms. People living with RA commonly make alterations to their dietary intake with the hope of improving their symptoms. This systematic review aims to discuss the effects of dietary interventions with and without omega-3 supplementation for the management of rheumatoid arthritis. Methods: A systematic review of randomised controlled trials (RCTs) and non-randomised controlled trials (NRCTs) will be conducted. MEDLINE, EMBASE, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Methodology Register) and CINAHL will be searched from inception without using date restrictions. Primary outcomes will include measures of disease activity, inflammation and quality of life among adults living with RA. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the methodological appraisal of the studies will be assessed independently by two different reviewers (TR and AG) using the Cochrane Risk-of-Bias Tool for RCTs, and Risk-of-Bias In Non-Randomised Studies Tool for NRCTs. Ethics and dissemination: Ethical approval is not required for this systematic review. Only publically available data from previously published studies will be used. The findings of this systematic review will be submitted for publication in a peer-reviewed journal and presented at relevant conferences. PROSPERO registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020147415 CRD42020147415 (11/02/2020).
KW - Rheumatoid arthritis
KW - diet
KW - non-randomised controlled trial
KW - omega-3
KW - protocol
KW - randomised controlled trials
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85166972877&partnerID=8YFLogxK
UR - https://doi.org/10.12688/hrbopenres.13136.1
U2 - 10.12688/hrbopenres.13136.1
DO - 10.12688/hrbopenres.13136.1
M3 - Article
C2 - 34056534
AN - SCOPUS:85166972877
SN - 2515-4826
VL - 3
SP - 72
JO - HRB Open Research
JF - HRB Open Research
M1 - 72
ER -