TY - JOUR
T1 - Differences in dopamine release and metabolism in rat striatal subregions following acute clozapine using in vivo microdialysis
AU - O'Connor, William T.
AU - Drew, Kelly L.
AU - Ungerstedt, Urban
PY - 1989/3/27
Y1 - 1989/3/27
N2 - This study examined and compared the effects of acute clozapine administration over a range of doses on the release of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in dorsolateral and fundus striata. Basal extracellular DA levels were significantly higher in the dorsolateral striatum. However, DOPAC levels were similar in both regions. Acute treatment with clozapine (40 mg/kg) was associated with an increase in extracellular dopamine in the dorsolateral striatum but not in the fundus. In contrast, an increase in extracellular DOPAC was seen in both regions following all doses of the drug; however, clozapine was more potent in the dorsolateral striatum than in the fundus. These results illustrate the functional heterogeneity of the striatum and in addition, indicate a possible dissociation between the effect of acute clozapine on DA release and DA metabolism.
AB - This study examined and compared the effects of acute clozapine administration over a range of doses on the release of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in dorsolateral and fundus striata. Basal extracellular DA levels were significantly higher in the dorsolateral striatum. However, DOPAC levels were similar in both regions. Acute treatment with clozapine (40 mg/kg) was associated with an increase in extracellular dopamine in the dorsolateral striatum but not in the fundus. In contrast, an increase in extracellular DOPAC was seen in both regions following all doses of the drug; however, clozapine was more potent in the dorsolateral striatum than in the fundus. These results illustrate the functional heterogeneity of the striatum and in addition, indicate a possible dissociation between the effect of acute clozapine on DA release and DA metabolism.
KW - Clozapine
KW - Dopamine metabolism
KW - Dopamine release
KW - Dorsolateral striatum
KW - Fundus striati
KW - Microdialysis
KW - Ventromedial striatum
UR - http://www.scopus.com/inward/record.url?scp=0024498607&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(89)90512-0
DO - 10.1016/0304-3940(89)90512-0
M3 - Article
C2 - 2710415
AN - SCOPUS:0024498607
SN - 0304-3940
VL - 98
SP - 211
EP - 216
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -