Difficulties arising in reimbursement recommendations on new medicines due to inadequate reporting of population adjustment indirect comparison methods

Eileen M. Holmes; Joy Leahy; Cathal D. Walsh; Arthur White; Peter T. Donnan; Felicity Lamrock

doi:10.1002/jrsm.1368

Difficulties arising in reimbursement recommendations on new medicines due to inadequate reporting of population adjustment indirect comparison methods

Eileen M. Holmes
, Joy Leahy
, Cathal D. Walsh
, Arthur White
, Peter T. Donnan
, Felicity Lamrock

Department of Mathematics and Statistics

Research output: Contribution to journal › Article › peer-review

Abstract

Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe some shared observations on areas where reporting of population-adjustment indirect comparison methods is causing uncertainty in our recommendations to decision-making committees when assessing reimbursement of medicines.

Original language	English
Pages (from-to)	615-617
Number of pages	3
Journal	Research Synthesis Methods
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/jrsm.1368
Publication status	Published - 1 Dec 2019

Keywords

decision making
evidence synthesis
population-adjusted indirect comparisons
statistical models

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10.1002/jrsm.1368

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abstract = "Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe some shared observations on areas where reporting of population-adjustment indirect comparison methods is causing uncertainty in our recommendations to decision-making committees when assessing reimbursement of medicines.",

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AU - Donnan, Peter T.

AU - Lamrock, Felicity

PY - 2019/12/1

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KW - evidence synthesis

KW - population-adjusted indirect comparisons

KW - statistical models

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Difficulties arising in reimbursement recommendations on new medicines due to inadequate reporting of population adjustment indirect comparison methods

Abstract

Keywords

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