TY - JOUR
T1 - Discrete countercurrent contacting
T2 - An experimental method for developing continuous countercurrent reactors
AU - Den Hollander, Jeroen L.
AU - Aversente, Antonio
AU - Diender, Marjon B.
AU - Straathof, Adrie J.J.
AU - Van Der Wielen, Luuk A.M.
PY - 2005/1/5
Y1 - 2005/1/5
N2 - To facilitate experimental studies on Countercurrent reactors, a discrete contacting mode was worked out experimentally and theoretically. Enzymatic hydrolysis of penicillin G to phenylacetic acid and 6-aminopenicillanic acid was carried out in biphasic aqueous organic systems without pH control. The two phases were countercurrently contacted in a discrete manner, so that equilibrium was reached in each stage. Sets of three and five shake flasks served to mimic equilibrium stages in the Countercurrent setup. It was shown that discrete Countercurrent contact leads to the same extent of improvement of the equilibrium conversion as continuous countercurrent contact does, when compared to the batch situation. Therefore, discrete experiments may be used to simplify the development of continuous Countercurrent reactors.
AB - To facilitate experimental studies on Countercurrent reactors, a discrete contacting mode was worked out experimentally and theoretically. Enzymatic hydrolysis of penicillin G to phenylacetic acid and 6-aminopenicillanic acid was carried out in biphasic aqueous organic systems without pH control. The two phases were countercurrently contacted in a discrete manner, so that equilibrium was reached in each stage. Sets of three and five shake flasks served to mimic equilibrium stages in the Countercurrent setup. It was shown that discrete Countercurrent contact leads to the same extent of improvement of the equilibrium conversion as continuous countercurrent contact does, when compared to the batch situation. Therefore, discrete experiments may be used to simplify the development of continuous Countercurrent reactors.
UR - http://www.scopus.com/inward/record.url?scp=11144227899&partnerID=8YFLogxK
U2 - 10.1021/ie0492395
DO - 10.1021/ie0492395
M3 - Article
AN - SCOPUS:11144227899
SN - 0888-5885
VL - 44
SP - 231
EP - 235
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 1
ER -