Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

Ghulam Md Ashraf; Mahmoud Ahmed Ebada; Mohd Suhail; Ashraf Ali; Md Sahab Uddin; Anwar L. Bilgrami; Asma Perveen; Amjad Husain; Mohd Tarique; Abdul Hafeez; Athanasios Alexiou; Ausaf Ahmad; Rajnish Kumar; Naheed Banu; Agnieszka Najda; Amany A. Sayed; Ghadeer M. Albadrani; Mohamed M. Abdel-Daim; Ilaria Peluso; George E. Barreto

doi:10.1155/2021/4572471

Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

Ghulam Md Ashraf
, Mahmoud Ahmed Ebada
, Mohd Suhail
, Ashraf Ali
, Md Sahab Uddin
, Anwar L. Bilgrami
, Asma Perveen
, Amjad Husain
, Mohd Tarique
, Abdul Hafeez
, Athanasios Alexiou
, Ausaf Ahmad
, Rajnish Kumar
, Naheed Banu
, Agnieszka Najda
, Amany A. Sayed
, Ghadeer M. Albadrani
, Mohamed M. Abdel-Daim
, Ilaria Peluso
, George E. Barreto

King Fahd Medical Research Center
Faculty of Applied Medical Sciences, King Abdulaziz University
Zagazig University
National Hepatology and Tropical Medicine Research Institute
University of Foggia
Southeast University, Dhaka
Rutgers - The State University of New Jersey, New Brunswick
King Abdulaziz University
Glocal University
Indian Institute of Science Education and Research Bhopal
University of Missouri
Novel Global Community Educational Foundation
AFNP Med
Amity University, Noida
Qassim University
University of Life Sciences in Lublin
Cairo University
Princess Nourah Bint Abdulrahman University
Faculty of Veterinary Medicine
Council for Agricultural Research and Economics

Research output: Contribution to journal › Review article › peer-review

Abstract

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.

Original language	English
Article number	4572471
Journal	Oxidative Medicine and Cellular Longevity
Volume	2021
DOIs	https://doi.org/10.1155/2021/4572471
Publication status	Published - 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1155/2021/4572471

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Ashraf, G. M., Ebada, M. A., Suhail, M., Ali, A., Uddin, M. S., Bilgrami, A. L., Perveen, A., Husain, A., Tarique, M., Hafeez, A., Alexiou, A., Ahmad, A., Kumar, R., Banu, N., Najda, A., Sayed, A. A., Albadrani, G. M., Abdel-Daim, M. M., Peluso, I., & Barreto, G. E. (2021). Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies. Oxidative Medicine and Cellular Longevity, 2021, Article 4572471. https://doi.org/10.1155/2021/4572471

@article{56f252f545da464f9b5338afb48d11f9,

title = "Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies",

abstract = "The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.",

author = "Ashraf, \{Ghulam Md\} and Ebada, \{Mahmoud Ahmed\} and Mohd Suhail and Ashraf Ali and Uddin, \{Md Sahab\} and Bilgrami, \{Anwar L.\} and Asma Perveen and Amjad Husain and Mohd Tarique and Abdul Hafeez and Athanasios Alexiou and Ausaf Ahmad and Rajnish Kumar and Naheed Banu and Agnieszka Najda and Sayed, \{Amany A.\} and Albadrani, \{Ghadeer M.\} and Abdel-Daim, \{Mohamed M.\} and Ilaria Peluso and Barreto, \{George E.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Ghulam Md Ashraf et al.",

year = "2021",

doi = "10.1155/2021/4572471",

language = "English",

volume = "2021",

journal = "Oxidative Medicine and Cellular Longevity",

issn = "1942-0900",

}

Ashraf, GM, Ebada, MA, Suhail, M, Ali, A, Uddin, MS, Bilgrami, AL, Perveen, A, Husain, A, Tarique, M, Hafeez, A, Alexiou, A, Ahmad, A, Kumar, R, Banu, N, Najda, A, Sayed, AA, Albadrani, GM, Abdel-Daim, MM, Peluso, I & Barreto, GE 2021, 'Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies', Oxidative Medicine and Cellular Longevity, vol. 2021, 4572471. https://doi.org/10.1155/2021/4572471

TY - JOUR

T1 - Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes

T2 - From Molecular Mechanisms to Potential Therapeutic Strategies

AU - Ashraf, Ghulam Md

AU - Ebada, Mahmoud Ahmed

AU - Suhail, Mohd

AU - Ali, Ashraf

AU - Uddin, Md Sahab

AU - Bilgrami, Anwar L.

AU - Perveen, Asma

AU - Husain, Amjad

AU - Tarique, Mohd

AU - Hafeez, Abdul

AU - Alexiou, Athanasios

AU - Ahmad, Ausaf

AU - Kumar, Rajnish

AU - Banu, Naheed

AU - Najda, Agnieszka

AU - Sayed, Amany A.

AU - Albadrani, Ghadeer M.

AU - Abdel-Daim, Mohamed M.

AU - Peluso, Ilaria

AU - Barreto, George E.

PY - 2021

Y1 - 2021

N2 - The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.

AB - The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.

UR - https://www.scopus.com/pages/publications/85103214639

U2 - 10.1155/2021/4572471

DO - 10.1155/2021/4572471

M3 - Review article

C2 - 33747345

AN - SCOPUS:85103214639

SN - 1942-0900

VL - 2021

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

M1 - 4572471

ER -

Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies

Abstract

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