Diversity in a simple co-crystal: Racemic and kryptoracemic behaviour

U. B. Rao Khandavilli, Matteo Lusi, Balakrishna R. Bhogala, Anita R. Maguire, Matthias Stein, Simon E. Lawrence

Research output: Contribution to journalArticlepeer-review

Abstract

The crystal structure containing (±)-3-methyl-2-phenylbutyramide with salicylic acid is the first example of a kryptoracemate co-crystal. It exhibits the first temperature mediated reversible single-crystal to single-crystal transition between two kryptoracemate forms, in addition to crystallising in another, racemic, form. Theoretical calculations and structural analysis reveal that there are only small differences in both energy and packing arrangements between the three forms. These results suggest that co-crystals can be an opportunity to investigate kryptoracemate behaviour.

Original languageEnglish
Pages (from-to)8309-8312
Number of pages4
JournalChemical Communications
Volume52
Issue number53
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'Diversity in a simple co-crystal: Racemic and kryptoracemic behaviour'. Together they form a unique fingerprint.

Cite this