Dopamine D1 receptor-mediated facilitation of GABAergic neurotransmission in the rat strioentppeduncular pathway and its modulation by adenosine A1 receptor-mediated mechanisms

Sergi Ferré, William T. O'Connor, Per Svenningsson, Lars Björklund, Jakob Lindberg, Barbro Tinner, Ingrid Strömberg, Menek Goldstein, Sven Ove Ögren, Urban Ungerstedt, Bertil B. Fredholm, Kjell Fuxe

Research output: Contribution to journalArticlepeer-review

Abstract

By using in vivo microdialysis it was found that one of the main functions of striatal dopamine D1 receptors is to selectively facilitate GABAergic neurotransmission in the 'direct' strioentopeduncular pathway. D1 receptors localized in the entopeduncular nucleus were also found to facilitate GABA release. However, results obtained from in vivo microdialysis, in vivo electrochemistry, immunohistochemistry and confocal laser microscopy suggested that entopeduncular D1 receptors could only be activated under pharmacological conditions. Adenosine A1 receptors were found to antagonistically modulate the D1-mediated regulation of the strioentopeduncular pathway. Furthermore, using in situ hybridization D1 and A1 receptors were shown to be colocalized in medium-sized striatal neurons. These results show that the strioentopeduncular neuron is a main locus for adenosine-dopamine interactions in the brain.

Original languageEnglish
Pages (from-to)1545-1553
Number of pages9
JournalEuropean Journal of Neuroscience
Volume8
Issue number7
DOIs
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Encephalin
  • Entopeduncular nucleus
  • Globus pallidus
  • Substance P

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