TY - JOUR
T1 - Effect of resveratrol supplementation on cognitive performance and mood in adults
T2 - A systematic literature review and meta-analysis of randomized controlled trials
AU - Marx, Wolfgang
AU - Kelly, Jaimon T.
AU - Marshall, Skye
AU - Cutajar, Jennifer
AU - Annois, Brigitte
AU - Pipingas, Andrew
AU - Tierney, Audrey
AU - Itsiopoulos, Catherine
N1 - Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of the International Life Sciences Institute.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Context: The aim of this systematic review was to evaluate clinical trial data regarding the effect of resveratrol supplementation on cognitive performance and mood in populations that are healthy and in the clinical setting. Data Sources: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review of randomized controlled trials was conducted. Data Extraction: A meta-analysis was also conducted to determine treatment effect on the following cognitive domains and mental processes: processing speed, number facility, memory, and mood. Risk of bias was assessed using the Cochrane Collaboration Risk of Bias tool. Quality of the body of evidence was assessed by evidence for each outcome related to cognitive function for which data was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Results: Ten studies were included. Three studies found resveratrol supplementation significantly improved some measures of cognitive performance, 2 reported mixed findings, and 5 found no effect. When data were pooled, resveratrol supplementation had a significant effect on delayed recognition (standardized mean difference [SMD], 0.39; 95% confidence interval [CI], 0.08-0.70; I2 ¼ 0%; P ¼ 0.01; n ¼ 3 studies; n ¼ 166 participants) and negative mood (SMD, 0.18; 95%CI, 0.31 to 0.05; I2 ¼ 0%; P ¼ 0.006; n ¼ 3 studies; n ¼ 163 participants). Included studies generally had low risk of bias and were of moderate or high quality. Conclusions: The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.
AB - Context: The aim of this systematic review was to evaluate clinical trial data regarding the effect of resveratrol supplementation on cognitive performance and mood in populations that are healthy and in the clinical setting. Data Sources: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review of randomized controlled trials was conducted. Data Extraction: A meta-analysis was also conducted to determine treatment effect on the following cognitive domains and mental processes: processing speed, number facility, memory, and mood. Risk of bias was assessed using the Cochrane Collaboration Risk of Bias tool. Quality of the body of evidence was assessed by evidence for each outcome related to cognitive function for which data was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). Results: Ten studies were included. Three studies found resveratrol supplementation significantly improved some measures of cognitive performance, 2 reported mixed findings, and 5 found no effect. When data were pooled, resveratrol supplementation had a significant effect on delayed recognition (standardized mean difference [SMD], 0.39; 95% confidence interval [CI], 0.08-0.70; I2 ¼ 0%; P ¼ 0.01; n ¼ 3 studies; n ¼ 166 participants) and negative mood (SMD, 0.18; 95%CI, 0.31 to 0.05; I2 ¼ 0%; P ¼ 0.006; n ¼ 3 studies; n ¼ 163 participants). Included studies generally had low risk of bias and were of moderate or high quality. Conclusions: The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.
KW - Cognitive performance
KW - Dietary supplement
KW - Polyphenol
KW - Resveratrol
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85053846175&partnerID=8YFLogxK
U2 - 10.1093/nutrit/nuy010
DO - 10.1093/nutrit/nuy010
M3 - Review article
C2 - 29596658
AN - SCOPUS:85053846175
SN - 0029-6643
VL - 76
SP - 432
EP - 443
JO - Nutrition Reviews
JF - Nutrition Reviews
IS - 6
ER -