TY - JOUR
T1 - Effectiveness of anthocyanin-containing foods and nutraceuticals in mitigating oxidative stress, inflammation, and cardiovascular health-related biomarkers
T2 - a systematic review of animal and human interventions
AU - Mohammadi, Nima
AU - Farrell, Michelle
AU - O'Sullivan, Laura
AU - Langan, Andrea
AU - Franchin, Marcelo
AU - Azevedo, Luciana
AU - Granato, Daniel
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/3/8
Y1 - 2024/3/8
N2 - Cardiovascular diseases (CVDs) are a group of chronic health disorders prevalent worldwide that claim millions of lives yearly. Inflammation and oxidative stress are intricately associated with myocardial tissue damage, endothelial dysfunction, and increased odds of heart failure. Thus, dietary strategies aimed at decreasing the odds of CVDs are paramount. In this regard, the consumption of anthocyanins, natural pigments found in edible flowers, fruits, and vegetables, has attracted attention due to their potential to promote cardiovascular health. The main mechanisms of action linked with their protective effects on antioxidant and anti-inflammatory activities, serum lipid profile modulation, and other cardiovascular health parameters are explained and exemplified. However, little is known about the dose-dependency nature of the effects, which anthocyanin has better efficiency, and whether anthocyanin-containing foods display better in vivo efficacy than nutraceuticals (i.e., concentrated extracts containing higher levels of anthocyanins than foods). Thus, this systematic review focused on determining the effects of anthocyanin-containing foods and nutraceuticals on biomarkers associated with CVDs using animal studies and human interventions supported by in vitro mechanistic insights. Overall, the results showed that the regular consumption of anthocyanin-containing foods and nutraceuticals improved vascular function, lipid profile, and antioxidant and anti-inflammatory effects. The daily dosage, the participants’ health status, and the duration of the intervention also significantly influenced the results.
AB - Cardiovascular diseases (CVDs) are a group of chronic health disorders prevalent worldwide that claim millions of lives yearly. Inflammation and oxidative stress are intricately associated with myocardial tissue damage, endothelial dysfunction, and increased odds of heart failure. Thus, dietary strategies aimed at decreasing the odds of CVDs are paramount. In this regard, the consumption of anthocyanins, natural pigments found in edible flowers, fruits, and vegetables, has attracted attention due to their potential to promote cardiovascular health. The main mechanisms of action linked with their protective effects on antioxidant and anti-inflammatory activities, serum lipid profile modulation, and other cardiovascular health parameters are explained and exemplified. However, little is known about the dose-dependency nature of the effects, which anthocyanin has better efficiency, and whether anthocyanin-containing foods display better in vivo efficacy than nutraceuticals (i.e., concentrated extracts containing higher levels of anthocyanins than foods). Thus, this systematic review focused on determining the effects of anthocyanin-containing foods and nutraceuticals on biomarkers associated with CVDs using animal studies and human interventions supported by in vitro mechanistic insights. Overall, the results showed that the regular consumption of anthocyanin-containing foods and nutraceuticals improved vascular function, lipid profile, and antioxidant and anti-inflammatory effects. The daily dosage, the participants’ health status, and the duration of the intervention also significantly influenced the results.
KW - Animals
KW - Humans
KW - Anthocyanins/pharmacology
KW - Anti-Inflammatory Agents/pharmacology
KW - Antioxidants/pharmacology
KW - Biomarkers/blood
KW - Cardiovascular Diseases/prevention & control
KW - Dietary Supplements
KW - Inflammation/drug therapy
KW - Oxidative Stress/drug effects
UR - http://www.scopus.com/inward/record.url?scp=85187685463&partnerID=8YFLogxK
U2 - 10.1039/d3fo04579j
DO - 10.1039/d3fo04579j
M3 - Article
C2 - 38482946
AN - SCOPUS:85187685463
SN - 2042-6496
VL - 15
SP - 3274
EP - 3299
JO - Food and Function
JF - Food and Function
IS - 7
ER -