TY - JOUR
T1 - Effects of curcumin on mitochondria in neurodegenerative diseases
AU - Bagheri, Hossein
AU - Ghasemi, Faezeh
AU - Barreto, George E.
AU - Rafiee, Rouhullah
AU - Sathyapalan, Thozhukat
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2019 International Union of Biochemistry and Molecular Biology
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, among others. There is a growing evidence that mitochondrial dysfunction and its related mutations in the form of oxidative/nitrosative stress and neurotoxic compounds play major roles in the pathogenesis of various NDs. Curcumin, a polyphenol and nontoxic compound, obtained from turmeric, has been shown to have a therapeutic beneficial effect in various disorders especially on the CNS cells. It has been shown that curcumin has considerable neuro- and mitochondria-protective properties against broad-spectrum neurotoxic compounds and diseases/injury-associating NDs. In this article, we have reviewed the various effects of curcumin on mitochondrial dysfunction in NDs.
AB - Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, among others. There is a growing evidence that mitochondrial dysfunction and its related mutations in the form of oxidative/nitrosative stress and neurotoxic compounds play major roles in the pathogenesis of various NDs. Curcumin, a polyphenol and nontoxic compound, obtained from turmeric, has been shown to have a therapeutic beneficial effect in various disorders especially on the CNS cells. It has been shown that curcumin has considerable neuro- and mitochondria-protective properties against broad-spectrum neurotoxic compounds and diseases/injury-associating NDs. In this article, we have reviewed the various effects of curcumin on mitochondrial dysfunction in NDs.
KW - curcumin
KW - mitochondrial dysfunction
KW - mitochondrion
KW - neurodegenerative diseases
UR - http://www.scopus.com/inward/record.url?scp=85073984830&partnerID=8YFLogxK
U2 - 10.1002/biof.1566
DO - 10.1002/biof.1566
M3 - Review article
C2 - 31580521
AN - SCOPUS:85073984830
SN - 0951-6433
VL - 46
SP - 5
EP - 20
JO - BioFactors
JF - BioFactors
IS - 1
ER -