TY - JOUR
T1 - Effects of frequency, intensity, duration and volume of walking interventions on CVD risk factors
T2 - A systematic review and meta-regression analysis of randomised controlled trials among inactive healthy adults
AU - Oja, Pekka
AU - Kelly, Paul
AU - Murtagh, Elaine M.
AU - Murphy, Marie H.
AU - Foster, Charlie
AU - Titze, Sylvia
N1 - Publisher Copyright:
© 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - Objective Walking interventions in healthy populations show clinically relevant improvements for many cardiovascular disease (CVD) risk factors. We aimed to assess the changes in CVD risk factors and the dose-response relationship between frequency, intensity, duration and volume of walking and cardiovascular risk factors based on randomised controlled trials (RCTs). Design A systematic review with meta-analysis and meta-regression. Data sources Four electronic databases searched from January 1971 to April 2017. Eligibility criteria Walking RCTs reporting one or more CVD risk factor outcomes; trials including at least one group with walking intervention and a no-walking control group; duration =8 weeks; participants =18 years old, inactive but healthy; risk factors assessed preintervention and postintervention; English-language articles in peer-reviewed journals. results Thirty-seven RCTs, involving 2001 participants (81% women) and assessing 13 CVD risk factors, were identifed. Pooled meta-analysis showed favourable effects (P≥0.05) of walking intervention for seven CVD risk factors (body mass, body mass index, body fat, systolic and diastolic blood pressure, fasting glucose and VO 2max). There were no signifcant effects (P>0.05) for waist circumference, waist-to-hip ratio and four blood lipid variables. Despite testing 91 possible dose-response relationships, linear meta-regression analysis adjusted for age indicated just 7 (or 7.7%) statistically signifcant fndings. summary/conclusion Walking interventions beneft a number of CVD risk factors. Despite multiple studies and tested metrics, only a few dose-response relationships were identifed and the possibility of chance fndings cannot be ruled out. There is insuffcient evidence to quantify the frequency, length, bout duration, intensity and volume of the walking required to improve CVD risk factors.
AB - Objective Walking interventions in healthy populations show clinically relevant improvements for many cardiovascular disease (CVD) risk factors. We aimed to assess the changes in CVD risk factors and the dose-response relationship between frequency, intensity, duration and volume of walking and cardiovascular risk factors based on randomised controlled trials (RCTs). Design A systematic review with meta-analysis and meta-regression. Data sources Four electronic databases searched from January 1971 to April 2017. Eligibility criteria Walking RCTs reporting one or more CVD risk factor outcomes; trials including at least one group with walking intervention and a no-walking control group; duration =8 weeks; participants =18 years old, inactive but healthy; risk factors assessed preintervention and postintervention; English-language articles in peer-reviewed journals. results Thirty-seven RCTs, involving 2001 participants (81% women) and assessing 13 CVD risk factors, were identifed. Pooled meta-analysis showed favourable effects (P≥0.05) of walking intervention for seven CVD risk factors (body mass, body mass index, body fat, systolic and diastolic blood pressure, fasting glucose and VO 2max). There were no signifcant effects (P>0.05) for waist circumference, waist-to-hip ratio and four blood lipid variables. Despite testing 91 possible dose-response relationships, linear meta-regression analysis adjusted for age indicated just 7 (or 7.7%) statistically signifcant fndings. summary/conclusion Walking interventions beneft a number of CVD risk factors. Despite multiple studies and tested metrics, only a few dose-response relationships were identifed and the possibility of chance fndings cannot be ruled out. There is insuffcient evidence to quantify the frequency, length, bout duration, intensity and volume of the walking required to improve CVD risk factors.
UR - http://www.scopus.com/inward/record.url?scp=85049182401&partnerID=8YFLogxK
U2 - 10.1136/bjsports-2017-098558
DO - 10.1136/bjsports-2017-098558
M3 - Article
C2 - 29858464
AN - SCOPUS:85049182401
SN - 0306-3674
VL - 52
SP - 769
EP - 775
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 12
ER -