Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies

Javad Motaharinia, Yunes Panahi, George E. Barreto, Fatemeh Beiraghdar, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Drug-induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti-inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug-induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug-induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.

Original languageEnglish
Pages (from-to)690-702
Number of pages13
JournalBioFactors
Volume45
Issue number5
DOIs
Publication statusPublished - 1 Sep 2019
Externally publishedYes

Keywords

  • acute kidney injury
  • Curcuma longa
  • Curcumin
  • nephroprotection
  • nephrotoxicity

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