TY - JOUR
T1 - Electronic effects of linker substitution on Lewis acid catalysis with metal-organic frameworks
AU - Vermoortele, Frederik
AU - Vandichel, Matthias
AU - Van De Voorde, Ben
AU - Ameloot, Rob
AU - Waroquier, Michel
AU - Van Speybroeck, Veronique
AU - De Vos, Dirk E.
PY - 2012/5/14
Y1 - 2012/5/14
N2 - Functionalized linkers can greatly increase the activity of metal-organic framework (MOF) catalysts with coordinatively unsaturated sites. A clear linear free-energy relationship (LFER) was found between Hammett m values of the linker substituents X and the rate k X of a carbonyl-ene reaction. This is the first LFER ever observed for MOF catalysts. A 56-fold increase in rate was found when the substituent is a nitro group (see picture).
AB - Functionalized linkers can greatly increase the activity of metal-organic framework (MOF) catalysts with coordinatively unsaturated sites. A clear linear free-energy relationship (LFER) was found between Hammett m values of the linker substituents X and the rate k X of a carbonyl-ene reaction. This is the first LFER ever observed for MOF catalysts. A 56-fold increase in rate was found when the substituent is a nitro group (see picture).
KW - heterogeneous catalysis
KW - Lewis acidity
KW - metal-organic framework
KW - structure-activity relationships
KW - substituent effects
UR - http://www.scopus.com/inward/record.url?scp=84860855938&partnerID=8YFLogxK
U2 - 10.1002/anie.201108565
DO - 10.1002/anie.201108565
M3 - Article
AN - SCOPUS:84860855938
SN - 1433-7851
VL - 51
SP - 4887
EP - 4890
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 20
ER -