TY - JOUR
T1 - Electrotherapy of tumour cells using flexible electrode arrays
AU - Soden, Declan
AU - Morrissey, Anthony
AU - Collins, Christopher
AU - Piggott, John
AU - Larkin, John
AU - Norman, A.
AU - Aarons, Simon
AU - Dunne, Colum
AU - O'Sullivan, Gerald C.
PY - 2004/9/29
Y1 - 2004/9/29
N2 - The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.
AB - The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.
KW - Cancer treatment
KW - Electroporation
KW - Gene therapy
KW - Microelectrodes
UR - http://www.scopus.com/inward/record.url?scp=14744288765&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2004.04.087
DO - 10.1016/j.snb.2004.04.087
M3 - Article
AN - SCOPUS:14744288765
SN - 0925-4005
VL - 103
SP - 219
EP - 224
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
IS - 1-2
ER -