Electrotherapy of tumour cells using flexible electrode arrays

Declan Soden, Anthony Morrissey, Christopher Collins, John Piggott, John Larkin, A. Norman, Simon Aarons, Colum Dunne, Gerald C. O'Sullivan

Research output: Contribution to journalArticlepeer-review

Abstract

The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume103
Issue number1-2
DOIs
Publication statusPublished - 29 Sep 2004
Externally publishedYes

Keywords

  • Cancer treatment
  • Electroporation
  • Gene therapy
  • Microelectrodes

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