Electrotherapy of tumour cells using flexible electrode arrays

Declan Soden; Anthony Morrissey; Christopher Collins; John Piggott; John Larkin; A. Norman; Simon Aarons; Colum Dunne; Gerald C. O'Sullivan

doi:10.1016/j.snb.2004.04.087

Electrotherapy of tumour cells using flexible electrode arrays

Declan Soden
, Anthony Morrissey
, Christopher Collins
, John Piggott
, John Larkin
, A. Norman
, Simon Aarons
, Colum Dunne
, Gerald C. O'Sullivan

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.

Original language	English
Pages (from-to)	219-224
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	103
Issue number	1-2
DOIs	https://doi.org/10.1016/j.snb.2004.04.087
Publication status	Published - 29 Sep 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer treatment
Electroporation
Gene therapy
Microelectrodes

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10.1016/j.snb.2004.04.087

Cite this

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title = "Electrotherapy of tumour cells using flexible electrode arrays",

abstract = "The process of therapeutic {"}electroporation{"} involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB{\texttrademark} software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.",

keywords = "Cancer treatment, Electroporation, Gene therapy, Microelectrodes",

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T1 - Electrotherapy of tumour cells using flexible electrode arrays

AU - Soden, Declan

AU - Morrissey, Anthony

AU - Collins, Christopher

AU - Piggott, John

AU - Larkin, John

AU - Norman, A.

AU - Aarons, Simon

AU - Dunne, Colum

AU - O'Sullivan, Gerald C.

PY - 2004/9/29

Y1 - 2004/9/29

N2 - The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.

AB - The process of therapeutic "electroporation" involves application of electric fields to target tumour cells, thereby rendering them transiently porous such that uptake of any deliberately introduced therapeutic agent present will be enhanced. The objective of this research programme is the development of flexible electrode arrays for incorporation into microsystem devices, and assessment of their efficacy in delivering selected genetic and pharmaceutical anti-cancer therapies. Gold electrodes were fabricated on flexible polyimide substrates following predictive modelling and simulation of electric fields using FEMLAB™ software. Subsequent assessment of electroporation efficiency involved enumeration of viable tumour cells and, where appropriate, quantification of emitted fluorescence by genetically altered cells.

KW - Cancer treatment

KW - Electroporation

KW - Gene therapy

KW - Microelectrodes

UR - https://www.scopus.com/pages/publications/14744288765

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DO - 10.1016/j.snb.2004.04.087

M3 - Article

AN - SCOPUS:14744288765

SN - 0925-4005

VL - 103

SP - 219

EP - 224

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

IS - 1-2

ER -

Electrotherapy of tumour cells using flexible electrode arrays

Abstract

UN SDGs

Keywords

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