Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus

P. M. Thomas, J. P. Phillips, N. Delanty, W. T. O'Connor

Research output: Contribution to journalArticlepeer-review

Abstract

We report preliminary results from four patients subjected to hippocampal electrocorticography and microdialysis during temporal lobe epilepsy surgery. In two cases, spontaneously vigorous hippocampal epileptiform activity (EA) was identified; basal dialysate levels for hippocampal glutamate, aspartate, and gamma-aminobutyric acid ranged from approximately 23- to 84-fold, 19- to 33-fold and 10- to 34-fold higher, respectively, compared to the two cases of minimal hippocampal EA. These findings represent the first intraoperative evidence of elevated extracellular levels of neuroactive amino acids within the spontaneously epileptiform human hippocampus.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalEpilepsy Research
Volume54
Issue number1
DOIs
Publication statusPublished - 1 Apr 2003
Externally publishedYes

Keywords

  • Aspartate
  • Gamma-aminobutyric acid
  • Glutamate
  • Hippocampus
  • Microdialysis
  • Temporal lobe epilepsy surgery

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