Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease

Katarzyna Mnich, Shirin Moghaddam, Patrick Browne, Timothy Counihan, Stephen P. Fitzgerald, Kenneth Martin, Ciaran Richardson, Afshin Samali, Adrienne M. Gorman

Research output: Contribution to journalArticlepeer-review

Abstract

Examination of post-mortem brain tissues has previously revealed a strong association between Parkinson’s disease (PD) pathophysiology and endoplasmic reticulum (ER) stress. Evidence in the literature regarding the circulation of ER stress-regulated factors released from neurons provides a rationale for investigating ER stress biomarkers in the blood to aid diagnosis of PD. The levels of ER stress-regulated proteins in serum collected from 29 PD patients and 24 non-PD controls were measured using enzyme-linked immunosorbent assays. A panel of four biomarkers, protein disulfide-isomerase A1, protein disulfide-isomerase A3, mesencephalic astrocyte-derived neurotrophic factor, and clusterin, together with age and gender had higher ability (area under the curve 0.64, sensitivity 66%, specificity 57%) and net benefit to discriminate PD patients from the non-PD group compared with other analyzed models. Addition of oligomeric and total α-synuclein to the model did not improve the diagnostic power of the biomarker panel. We provide evidence that ER stress-regulated proteins merit further investigation for their potential as diagnostic biomarkers of PD. Graphical Abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1476-1485
Number of pages10
JournalMolecular Neurobiology
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2023

Keywords

  • Biomarker
  • Chaperone
  • Endoplasmic reticulum (ER) stress
  • Parkinson’s disease (PD)
  • Serum

Fingerprint

Dive into the research topics of 'Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson’s Disease'. Together they form a unique fingerprint.

Cite this