Enhanced in vivo visualization of the microcirculation by topical application of fructose solution confirmed with correlation mapping optical coherence tomography

Joey Enfield, James McGrath, Susan M. Daly, Martin Leahy

Research output: Contribution to journalArticlepeer-review

Abstract

Changes within the microcirculation can provide an early indication of the onset of a plethora of ailments. Various techniques have thus been developed that enable the study of microcirculatory irregularities. Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique, which enables mapping of vasculature networks at the capillary level in a noninvasive and noncontact manner. This technique is an extension of conventional optical coherence tomography (OCT) and is therefore likewise limited in the penetration depth of ballistic photons in biological media. Optical clearing has previously been demonstrated to enhance the penetration depth and the imaging capabilities of OCT. In order to enhance the achievable maximum imaging depth, we propose the use of optical clearing in conjunction with the cmOCT technique. We demonstrate in vivo a 13% increase in OCT penetration depth by topical application of a high-concentration fructose solution, thereby enabling the visualization of vessel features at deeper depths within the tissue.

Original languageEnglish
Article number7101007
JournalJournal of Biomedical Optics
Volume21
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016
Externally publishedYes

Keywords

  • biomedical optical imaging
  • correlation mapping
  • microcirculation imaging
  • optical clearing
  • optical coherence tomography

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