Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Vinod Ravasaheb Shinde; Neeraja Revi; Sivasubramanian Murugappan; Surya Prakash Singh; Aravind Kumar Rengan

doi:10.1016/j.pdpdt.2022.102915

Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Vinod Ravasaheb Shinde, Neeraja Revi, Sivasubramanian Murugappan, Surya Prakash Singh, Aravind Kumar Rengan

Indian Institute of Technology Hyderabad

Research output: Contribution to journal › Review article › peer-review

Abstract

Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region.

Original language	English
Article number	102915
Pages (from-to)	102915
Journal	Photodiagnosis and Photodynamic Therapy
Volume	39
DOIs	https://doi.org/10.1016/j.pdpdt.2022.102915
Publication status	Published - Sep 2022
Externally published	Yes

Keywords

EPR
Extravasation
Microbubble
Microenvironment
Nanoparticles
PDT
Pharmacokinetics
Photodynamic Therapy
PTT
Ultrasound

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pdpdt.2022.102915

Cite this

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title = "Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles",

abstract = "Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region.",

keywords = "EPR, Extravasation, Microbubble, Microenvironment, Nanoparticles, PDT, Pharmacokinetics, Photodynamic Therapy, PTT, Ultrasound",

author = "Shinde, {Vinod Ravasaheb} and Neeraja Revi and Sivasubramanian Murugappan and Singh, {Surya Prakash} and Rengan, {Aravind Kumar}",

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year = "2022",

month = sep,

doi = "10.1016/j.pdpdt.2022.102915",

language = "English",

volume = "39",

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journal = "Photodiagnosis and Photodynamic Therapy",

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T1 - Enhanced permeability and retention effect

T2 - A key facilitator for solid tumor targeting by nanoparticles

AU - Shinde, Vinod Ravasaheb

AU - Revi, Neeraja

AU - Murugappan, Sivasubramanian

AU - Singh, Surya Prakash

AU - Rengan, Aravind Kumar

PY - 2022/9

Y1 - 2022/9

N2 - Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region.

AB - Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region.

KW - EPR

KW - Extravasation

KW - Microbubble

KW - Microenvironment

KW - Nanoparticles

KW - PDT

KW - Pharmacokinetics

KW - Photodynamic Therapy

KW - PTT

KW - Ultrasound

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U2 - 10.1016/j.pdpdt.2022.102915

DO - 10.1016/j.pdpdt.2022.102915

M3 - Review article

C2 - 35597441

AN - SCOPUS:85132853096

SN - 1572-1000

VL - 39

SP - 102915

JO - Photodiagnosis and Photodynamic Therapy

JF - Photodiagnosis and Photodynamic Therapy

M1 - 102915

ER -

Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

Abstract

Keywords

UN SDGs

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