TY - JOUR
T1 - Enzymatic Biofuel Cells for Self-Powered, Controlled Drug Release
AU - Xiao, Xinxin
AU - McGourty, Kieran Denis
AU - Magner, Edmond
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Self-powered drug-delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources are of significant interest for use in clinical applications. Osmium redox polymer-mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an additional CP-drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU), and 4′,6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug-release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug-release system that may be used in implantable devices.
AB - Self-powered drug-delivery systems based on conductive polymers (CPs) that eliminate the need for external power sources are of significant interest for use in clinical applications. Osmium redox polymer-mediated glucose/O2 enzymatic biofuel cells (EBFCs) were prepared with an additional CP-drug layer on the cathode. On discharging the EBFCs in the presence of glucose and dioxygen, model drug compounds incorporated in the CP layer were rapidly released with negligible amounts released when the EBFCs were held at open circuit. Controlled and ex situ release of three model compounds, ibuprofen (IBU), fluorescein (FLU), and 4′,6-diamidino-2-phenylindole (DAPI), was achieved with this self-powered drug-release system. DAPI released in situ in cell culture media was incorporated into retinal pigment epithelium (RPE) cells. This work demonstrates a proof-of-concept responsive drug-release system that may be used in implantable devices.
UR - http://www.scopus.com/inward/record.url?scp=85087467829&partnerID=8YFLogxK
U2 - 10.1021/jacs.0c05749
DO - 10.1021/jacs.0c05749
M3 - Article
C2 - 32510936
AN - SCOPUS:85087467829
SN - 0002-7863
VL - 142
SP - 11602
EP - 11609
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 26
ER -